Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates | Zendy

Hanna Wardell | Zendy; Jeffrey I. Campbell | Zendy; Christina VanderPluym | Zendy; Avika Dixit | Zendy

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Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Febrile Neonates

Author(s) -

Hanna Wardell,

Jeffrey I. Campbell,

Christina VanderPluym,

Avika Dixit

Publication year - 2020

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piaa084

Subject(s) - medicine , asymptomatic , coinfection , pediatrics , respiratory system , coronavirus , pediatric intensive care unit , intensive care unit , intensive care medicine , covid-19 , disease , infectious disease (medical specialty) , immunology , virus

Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients are mild or asymptomatic. However, infants have emerged at higher risk of hospitalization and severe outcomes in pediatric coronavirus disease 2019 (COVID-19). We report a case series of 4 full-term neonates hospitalized with fever and found to have SARS-CoV-2 infection with a spectrum of illness severities. Two neonates required admission to the intensive care unit for respiratory insufficiency and end organ involvement. Half of the patients were found to have a coinfection. One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. All neonates had favorable outcomes.

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