BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target | Zendy

Susan Morand | Zendy; Laura Stanbery | Zendy; Adam Walter | Zendy; Rodney P. Rocconi | Zendy; John Nemunaitis | Zendy

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BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target

Author(s) -

Susan Morand,

Laura Stanbery,

Adam Walter,

Rodney P. Rocconi,

John Nemunaitis

Publication year - 2020

Publication title -

jnci cancer spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.345

H-Index - 10

ISSN - 2515-5091

DOI - 10.1093/jncics/pkaa077

Subject(s) - autophagy , immune system , effector , antigen presentation , major histocompatibility complex , mutation , immunology , biology , medicine , genetics , t cell , gene , apoptosis

BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.

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