Open AccessOral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study
Author(s) -
Anil K. Chaturvedi,
Natalia Udaltsova,
Eric A. Engels,
Jed Abraham Katzel,
Elizabeth L. Yanik,
Hormuzd A. Katki,
Mark W. Lingen,
Michael J. Silverberg
Publication year - 2019
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djz238
Subject(s) - medicine , leukoplakia , cancer , incidence (geometry) , cohort , relative risk , population , hazard ratio , dysplasia , cohort study , retrospective cohort study , oral leukoplakia , confidence interval , physics , environmental health , optics
The optimal clinical management of oral precancer remains uncertain. We investigated the natural history of oral leukoplakia, the most common oral precancerous lesion, to estimate the relative and absolute risks of progression to cancer, the predictive accuracy of a clinician's decision to biopsy a leukoplakia vis-à-vis progression, and histopathologic predictors of progression.