Open AccessPrimary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy
Author(s) -
Michael Lattanzi,
Yesung Lee,
Danny Simpson,
Una Moran,
Farbod Darvishian,
Randie H. Kim,
Eva Hernando,
David Polsky,
Doug Hanniford,
Richard L. Shapiro,
Russell S. Berman,
Anna C. Pavlick,
Mathew Wilson,
Tomas Kirchhoff,
Jeffrey S. Weber,
Judy Zhong,
Iman Osman
Publication year - 2018
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djy086
Subject(s) - medicine , melanoma , hazard ratio , oncology , confidence interval , cohort , targeted therapy , superficial spreading melanoma , immunotherapy , epidemiology , proportional hazards model , nodular melanoma , histology , cancer , cancer research
Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular melanoma (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, and it is widely expected that NM and SSM would exhibit similar behavior once metastasized. Herein, we tested the hypothesis that primary histologic subtype is an independent predictor of survival and may impact response to treatment in the metastatic setting.