Open AccessHomologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications
Author(s) -
Roberto Moretto,
Andrew Elliott,
Jian Zhang,
Hajime Arai,
Marco Maria Germani,
Veronica Conca,
Joanne Xiu,
Phillip Stafford,
Matthew J. Oberley,
Jim Abraham,
David Spetzler,
Daniele Rossini,
Carlotta Antoniotti,
John L. Marshall,
Anthony F. Shields,
Gilberto Lopes,
Sara Lonardi,
Filippo Pietrantonio,
Gianluca Tomasello,
Alessandro Passardi,
Emiliano Tamburini,
Daniele Santini,
Giuseppe Aprile,
Gianluca Masi,
Alfredo Falcone,
HeinzJosef Lenz,
Michael Korn,
Chiara Cremolini
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab169
Subject(s) - microsatellite instability , colorectal cancer , homologous recombination , cancer research , dna mismatch repair , loss of heterozygosity , biology , cancer , microbiology and biotechnology , medicine , genetics , gene , microsatellite , allele
Tumors with homologous recombination deficiency (HRD) show high sensitivity to platinum salts and poly(ADP-ribose) polymerase-inhibitors in several malignancies. In colorectal cancer (CRC), the role of HRD alterations is mostly unknown.