Open AccessClinical Implications of Inter- and Intratumor Heterogeneity of Immune Cell Markers in Lung Cancer
Author(s) -
Wei Zhao,
Bin Zhu,
Amy Hutchinson,
Angela Cecilia Pesatori,
Dario Consonni,
Neil E. Caporaso,
Tongwu Zhang,
Difei Wang,
Jianxin Shi,
Maria Teresa Landi
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab157
Subject(s) - immune system , lung cancer , hazard ratio , biology , tumor microenvironment , cd8 , immunology , cancer research , medicine , oncology , confidence interval
Immune cell transcriptome signatures have been widely used to study the lung tumor microenvironment (TME). However, it is unclear to what extent the immune cell composition in the lung TME varies across histological and molecular subtypes (intertumor heterogeneity [inter-TH]) and within tumors (intratumor heterogeneity [ITH]) and whether ITH has any prognostic relevance.