Open AccessIdentification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated With an Immunosuppressive Tumor Microenvironment
Author(s) -
Takashi Semba,
Xiaoping Wang,
Xuemei Xie,
Evan N. Cohen,
James M. Reuben,
Kevin N. Dalby,
James P. Long,
Lan Thi Phi,
Debu Tripathy,
Naoto T. Ueno
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab128
Subject(s) - tumor microenvironment , triple negative breast cancer , cancer research , cd8 , ccl2 , tumor infiltrating lymphocytes , metastasis , breast cancer , immune system , tumor associated macrophage , biology , immunology , medicine , cancer , chemokine
Although an immunosuppressive tumor microenvironment (TME) is key for tumor progression, the molecular characteristics associated with the immunosuppressive TME remain unknown in triple-negative breast cancer (TNBC). Our previous functional proteomic study of TNBC tumors identified that C-JUN N-terminal kinase (JNK) pathway-related molecules were enriched in a cluster associated with the inflammatory pathway. However, the role of the JNK pathway in the TNBC TME is still unclear.