Open AccessThe Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer
Author(s) -
Kelly McCastlain,
Carrie R. Howell,
Catherine E. Welsh,
Zhaoming Wang,
Carmen L. Wilson,
Heather L. Mulder,
John Easton,
Ann C. Mertens,
Jinghui Zhang,
Yutaka Yasui,
Melissa M. Hudson,
Leslie L. Robison,
Mondira Kundu,
Kirsten K. Ness
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab084
Subject(s) - sarcopenia , medicine , interquartile range , odds ratio , confidence interval , cancer , young adult , oncology
Adult childhood cancer survivors are at risk for frailty, including low muscle mass and weakness (sarcopenia). Using peripheral blood mitochondrial DNA copy number (mtDNAcn) as a proxy for functional mitochondria, this study describes cross-sectional associations between mtDNAcn and sarcopenia among survivors.