Breast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion | Zendy

Song Yao | Zendy; TingYuan David Cheng | Zendy; Ahmed Elkhanany | Zendy; Li Yan | Zendy; Angela R. Omilian | Zendy; Scott I. Abrams | Zendy; Sharon S. Evans | Zendy; Chi-Chen Hong | Zendy; Qianya Qi | Zendy; Warren Davis | Zendy; Song Liu | Zendy; Elisa V. Bandera | Zendy; Kunle Odunsi | Zendy; Kazuaki Takabe | Zendy; Thaer Khoury | Zendy; Christine B. Ambrosone | Zendy

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Breast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion

Author(s) -

Song Yao,

TingYuan David Cheng,

Ahmed Elkhanany,

Li Yan,

Angela R. Omilian,

Scott I. Abrams,

Sharon S. Evans,

Chi-Chen Hong,

Qianya Qi,

Warren Davis,

Song Liu,

Elisa V. Bandera,

Kunle Odunsi,

Kazuaki Takabe,

Thaer Khoury,

Christine B. Ambrosone

Publication year - 2020

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djaa215

Subject(s) - immune system , cd8 , tumor microenvironment , biology , breast cancer , immunology , phenotype , cytotoxic t cell , medicine , cancer research , cancer , gene , genetics , in vitro

Blacks tend to have a stronger inflammatory immune response than Whites. We hypothesized that racial differences in host immunity also manifest in the tumor microenvironment, constituting part of a distinct aggressive tumor biology underlying higher mortality in Black women.

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