Open AccessBreast Tumor Microenvironment in Black Women: A Distinct Signature of CD8+ T-Cell Exhaustion
Author(s) -
Song Yao,
TingYuan David Cheng,
Ahmed Elkhanany,
Li Yan,
Angela R. Omilian,
Scott I. Abrams,
Sharon S. Evans,
Chi Chen Hong,
Qianya Qi,
Warren Davis,
Song Liu,
Elisa V. Bandera,
Kunle Odunsi,
Kazuaki Takabe,
Thaer Khoury,
Christine B. Ambrosone
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djaa215
Subject(s) - immune system , cd8 , tumor microenvironment , biology , breast cancer , immunology , phenotype , cytotoxic t cell , medicine , cancer research , cancer , gene , genetics , in vitro
Blacks tend to have a stronger inflammatory immune response than Whites. We hypothesized that racial differences in host immunity also manifest in the tumor microenvironment, constituting part of a distinct aggressive tumor biology underlying higher mortality in Black women.