Open AccessEarly-Life Body Adiposity and the Breast Tumor Transcriptome
Author(s) -
Jun Wang,
Cheng Peng,
Catherine Guranich,
Yujing J. Heng,
Gabrielle M. Baker,
Christopher A. Rubadue,
Kimberly Glass,
A. Heather Eliassen,
Rulla M. Tamimi,
Kornélia Polyák,
Susan E. Hankinson
Publication year - 2020
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djaa169
Subject(s) - transcriptome , downregulation and upregulation , pi3k/akt/mtor pathway , biology , cancer research , breast cancer , estrogen receptor , estrogen receptor alpha , endocrinology , medicine , cancer , signal transduction , gene , gene expression , microbiology and biotechnology , genetics
Cumulative epidemiologic evidence has shown that early-life adiposity is strongly inversely associated with breast cancer risk throughout life, independent of adult obesity. However, the molecular mechanisms remain poorly understood.