Open AccessGermline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer
Author(s) -
Burcu F. Darst,
Tokhir Dadaev,
Ed Saunders,
Xin Sheng,
Peggy Wan,
Loreall Pooler,
Lucy Xia,
Stephen J. Chanock,
Sonja I. Berndt,
Susan M. Gapstur,
Victoria L. Stevens,
Demetrius Albanês,
Stephanie J. Weinstein,
Vincent Gnanapragasam,
Graham G. Giles,
Tú Nguyen-Dumont,
Roger L. Milne,
Mark M. Pomerantz,
Julie A. Schmidt,
Lorelei A. Mucci,
William J. Catàlona,
Kurt N. Hetrick,
Kimberly F. Doheny,
Robert J. MacInnis,
Melissa C. Southey,
Rosalind Eeles,
Fredrik Wiklund,
Zsofia Kóte-Jarai,
David V. Conti,
Christopher A. Haiman
Publication year - 2020
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djaa132
Subject(s) - palb2 , allele , prostate cancer , odds ratio , germline , genetics , biology , gene , dna repair , medicine , oncology , cancer , cancer research , germline mutation , mutation
There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline variants in DNA repair genes are associated with aggressive PCa risk in a case-case study of aggressive vs nonaggressive disease.