Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer | Zendy

Burcu F. Darst | Zendy; Tokhir Dadaev | Zendy; Edward J. Saunders | Zendy; Xin Sheng | Zendy; Peggy Wan | Zendy; Loreall Pooler | Zendy; Lucy Xia | Zendy; Stephen J. Chanock | Zendy; Sonja I. Berndt | Zendy; Susan M. Gapstur | Zendy; Victoria L. Stevens | Zendy; Demetrius Albanes | Zendy; Stephanie J. Weinstein | Zendy; Vincent J. Gnanapragasam | Zendy; Graham G. Giles | Zendy; Tú NguyenDumont | Zendy; Roger L. Milne | Zendy; Mark M. Pomerantz | Zendy; Julie A. Schmidt | Zendy; Lorelei A. Mucci | Zendy; William J. Catàlona | Zendy; Kurt N. Hetrick | Zendy; Kimberly F. Doheny | Zendy; Robert J. MacInnis | Zendy; Melissa C. Southey | Zendy; Rosalind A. Eeles | Zendy; Fredrik Wiklund | Zendy; Zsofia KoteJarai | Zendy; David V. Conti | Zendy; Christopher A. Haiman | Zendy

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Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer

Author(s) -

Burcu F. Darst,

Tokhir Dadaev,

Edward J. Saunders,

Xin Sheng,

Peggy Wan,

Loreall Pooler,

Lucy Xia,

Stephen J. Chanock,

Sonja I. Berndt,

Susan M. Gapstur,

Victoria L. Stevens,

Demetrius Albanes,

Stephanie J. Weinstein,

Vincent J. Gnanapragasam,

Graham G. Giles,

Tú NguyenDumont,

Roger L. Milne,

Mark M. Pomerantz,

Julie A. Schmidt,

Lorelei A. Mucci,

William J. Catàlona,

Kurt N. Hetrick,

Kimberly F. Doheny,

Robert J. MacInnis,

Melissa C. Southey,

Rosalind A. Eeles,

Fredrik Wiklund,

Zsofia KoteJarai,

David V. Conti,

Christopher A. Haiman

Publication year - 2020

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djaa132

Subject(s) - palb2 , allele , odds ratio , prostate cancer , germline , genetics , gene , biology , dna repair , confidence interval , cancer , medicine , oncology , cancer research , germline mutation , mutation

There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline variants in DNA repair genes are associated with aggressive PCa risk in a case-case study of aggressive vs nonaggressive disease.

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