Open AccessHost Circadian Clock as a Control Point in Tumor Progression
Author(s) -
Elisabeth Filipski
Publication year - 2002
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/94.9.690
Subject(s) - circadian rhythm , medicine , endocrinology , corticosterone , analysis of variance , lesion , hypothalamus , biology , pathology , hormone
The circadian timing system controlled by the suprachiasmatic nuclei (SCN) of the hypothalamus regulates daily rhythms of motor activity and adrenocortical secretion. An alteration in these rhythms is associated with poor survival of patients with metastatic colorectal or breast cancer. We developed a mouse model to investigate the consequences of severe circadian dysfunction upon tumor growth.
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