Infant Metabolome in Relation to Prenatal DHA Supplementation and Maternal Single-Nucleotide Polymorphism rs174602: Secondary Analysis of a Randomized Controlled Trial in Mexico | Zendy

Sonia Tandon | Zendy; Inés González-Casanova | Zendy; Albino BarrazaVillarreal | Zendy; Isabelle Romieu | Zendy; Hans Demmelmair | Zendy; Dean P. Jones | Zendy; Berthold Koletzko | Zendy; Aryeh D. Stein | Zendy; Usha Ramakrishnan | Zendy

Open Access

Infant Metabolome in Relation to Prenatal DHA Supplementation and Maternal Single-Nucleotide Polymorphism rs174602: Secondary Analysis of a Randomized Controlled Trial in Mexico

Author(s) -

Sonia Tandon,

Inés González-Casanova,

Albino BarrazaVillarreal,

Isabelle Romieu,

Hans Demmelmair,

Dean P. Jones,

Berthold Koletzko,

Aryeh D. Stein,

Usha Ramakrishnan

Publication year - 2021

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.1093/jn/nxab276

Subject(s) - metabolome , single nucleotide polymorphism , randomized controlled trial , polymorphism (computer science) , medicine , pregnancy , biology , genetics , genotype , gene , metabolite

Although DHA (22:6n-3) is critical for fetal development, results from randomized controlled trials (RCTs) of prenatal DHA supplementation report inconsistent effects on offspring health. Variants in fatty acid desaturase (FADS) genes that regulate the conversion of n-3 and n-6 essential fatty acids into their biologically active derivatives may explain this heterogeneity.

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