Letrozole-Induced Polycystic Ovary Syndrome Attenuates Cystathionine-β Synthase mRNA and Protein Abundance in the Ovaries of Female Sprague Dawley Rats | Zendy

Amanda Bries | Zendy; J. L. Webb | Zendy; Brooke Vogel | Zendy; Claudia Carrillo | Zendy; Aileen F. Keating | Zendy; Samantha K Pritchard | Zendy; Gina Roslan | Zendy; Joshua W. Miller | Zendy; Kevin L. Schalinske | Zendy

Open Access

Letrozole-Induced Polycystic Ovary Syndrome Attenuates Cystathionine-β Synthase mRNA and Protein Abundance in the Ovaries of Female Sprague Dawley Rats

Author(s) -

Amanda Bries,

J. L. Webb,

Brooke Vogel,

Claudia Carrillo,

Aileen F. Keating,

Samantha K Pritchard,

Gina Roslan,

Joshua W. Miller,

Kevin L. Schalinske

Publication year - 2021

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.1093/jn/nxab038

Subject(s) - polycystic ovary , cystathionine beta synthase , endocrinology , medicine , ovary , messenger rna , letrozole , biology , chemistry , enzyme , obesity , gene , biochemistry , aromatase , insulin resistance , cancer , cysteine , breast cancer

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 10% of reproductive-aged women and leads to hyperandrogenism, anovulation, and infertility. PCOS has been associated with elevated serum homocysteine as well as altered methylation status; however, characterization of one-carbon metabolism (OCM) in PCOS remains incomplete.

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