Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase–Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle | Zendy

Tianzheng Yu | Zendy; Jacob Dohl | Zendy; Li Wang | Zendy; Yifan Chen | Zendy; Heath G. Gasier | Zendy; Patricia A. Deuster | Zendy

Open Access

Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase–Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle

Author(s) -

Tianzheng Yu,

Jacob Dohl,

Li Wang,

Yifan Chen,

Heath G. Gasier,

Patricia A. Deuster

Publication year - 2020

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.1093/jn/nxaa201

Subject(s) - c2c12 , curcumin , skeletal muscle , myocyte , nadph oxidase , redox , chemistry , mitochondrion , microbiology and biotechnology , reactive oxygen species , biochemistry , biology , myogenesis , endocrinology , organic chemistry

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the mitochondrial electron transport chain are the primary sources of reactive oxygen species (ROS). Previous studies have shown that severe heat exposure damages mitochondria and causes excessive mitochondrial ROS production that contributes to the pathogenesis of heat-related illnesses.

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