Open AccessDestruction of a Destructor: A New Avenue for Cancer Therapeutics Targeting the Wnt Pathway
Author(s) -
Chunming Liu,
Xi He
Publication year - 2009
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp040
Subject(s) - wnt signaling pathway , biology , cancer , beta catenin , cancer research , microbiology and biotechnology , computational biology , signal transduction , genetics
A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.
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