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Numerous biological processes are governed by the biological clock. Studies using  Drosophila melanogaster  (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H 2 O 2  induced stress in  D. melanogaster  was investigated.  D. melanogaster  flies were divided into four groups (group I – control, group II – H 2 O 2  (acute exposure), group III – quercetin, and group IV – quercetin + H 2 O 2  treated). Negative geotaxis assay, oxidative stress indicators (protein carbonyls, thiobarbituric reactive substances [TBARS]), and antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione-S-transferase [GST], glutathione peroxidase, and reduced glutathione [GSH]) were measured at 4 h intervals over 24 h and temporal expression of heat shock protein-70 (Hsp70), Upd1 (homolog of IL-6 in  Drosophila ), and nitric oxide synthase (Nos) was analyzed by Western blotting. Groups II and IV showed altered biochemical rhythms (compared with controls). Decreased mesor values of negative geotaxis, SOD, CAT, GST, and GSH were noticed in H 2 O 2 , increased mesor of oxidative stress indicators (TBARS and protein carbonyl content) and a reversibility of the rhythmic characteristics were conspicuous after quercetin treatment. The expression levels of Hsp70, Upd1, and Nos were noticeably maximum at 04:00. Significant elevation of expression by H 2 O 2  was nearly normalized by quercetin treatment. The possible mechanism by which quercetin modulates oxidant–antioxidant imbalance under oxidative stress could be ascribed to the modulation of the rhythmic properties. Our results will be helpful to understand the molecular interlink between circadian rhythm and oxidative stress mechanism.

Influence of Quercetin in the Temporal Regulation of Redox Homeostasis in Drosophila melanogaster