Open AccessIncorporation of Silver Nanoparticles in Hydrogel Matrices for Controlling Wound Infection
Author(s) -
Harpreet Pangli,
Saba Vatanpour,
Shamim Hortamani,
Reza B. Jalili,
Aziz Ghahary
Publication year - 2020
Publication title -
journal of burn care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.679
H-Index - 78
eISSN - 1559-0488
pISSN - 1559-047X
DOI - 10.1093/jbcr/iraa205
Subject(s) - silver nanoparticle , biocomposite , wound healing , medicine , nanotechnology , antimicrobial , wound dressing , biocompatible material , nanoparticle , biomedical engineering , materials science , surgery , microbiology and biotechnology , composite material , composite number , biology
For centuries, silver has been recognized for its antibacterial properties. With the development of nanotechnology, silver nanoparticles (AgNPs) have garnered significant attention for their diverse uses in antimicrobial gel formulations, dressings for wound healing, orthopedic applications, medical catheters and instruments, implants, and contact lens coatings. A major focus has been determining AgNPs' physical, chemical, and biological characteristics and their potential to be incorporated in biocomposite materials, particularly hydrogel scaffolds, for burn and wound healing. Though AgNPs have been rigorously explored and extensively utilized in medical and nonmedical applications, important research is still needed to elucidate their antibacterial activity when incorporated in wound-healing scaffolds. In this review, we provide an up-to-date, 10-yr (2010-2019), comprehensive literature review on advancements in the understanding of AgNP characteristics, including the particles' preparation and mechanisms of activity, and we explore various hydrogel scaffolds for delivering AgNPs.