Open AccessGrowing Trends in the Efficient and Selective Extraction of Compounds in Complex Matrices Using Molecularly Imprinted Polymers and Their Relevance to Toxicological Analysis
Author(s) -
Haley A Mulder,
Matthew S. Halquist
Publication year - 2020
Publication title -
journal of analytical toxicology.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.161
H-Index - 76
eISSN - 1945-2403
pISSN - 0146-4760
DOI - 10.1093/jat/bkaa079
Subject(s) - molecularly imprinted polymer , sample preparation , complex matrix , extraction (chemistry) , analyte , solid phase extraction , chromatography , matrix (chemical analysis) , forensic toxicology , drugs of abuse , chemistry , drug , organic chemistry , medicine , pharmacology , selectivity , catalysis
In the world of forensic and clinical toxicology, proper sample preparation is one of the key steps in identification and quantification of drugs of abuse. Traditional extraction methods such as solid-phase extraction and liquid-liquid extraction are often laborious and nonselective for the target analytes being measured. Molecularly imprinted polymers (MIPs) can be synthesized for sample extraction and their versatility allows the polymer to be employed in off-line, benchtop extractions or on/in-line instrument extractions, offering a faster and more selective sample preparation without the risk of interfering matrix effects. This review details the synthesis and applications of MIP materials for the extraction of drug compounds from biological matrices in publications from 1994 to today.