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A literature review and meta-analysis was conducted to determine the effects of dietary energy system (NE or ME), oil content of cDDGS, diet inclusion levels, and pig age on growth performance in pigs fed cDDGS-based diets. The mean differences (MD) of ADG, ADFI, and gain-to-feed ratio (G:F) were calculated and expressed as a percentage change relative to feeding corn-soybean meal (CSB)- and cDDGS-based diets to nursery (BW &amp;lt; 25kg) and growing-finishing (BW &amp;gt; 25kg) pigs. In addition, MD were determined in CSB- and cDDGS-based diets to determine the effects of supplementation of various types of exogenous enzymes with or without phytase on growth performance. A total of 27 studies with 106 growth performance observations were included in the non-enzyme supplemented dataset, and 36 studies with 84 observations for enzyme responses in CSB and cDDGS diets were in the enzyme dataset. Feeding the cDDGS diets resulted in decreased (P &amp;lt; 0.01) the MD of ADG (- 4.27%) and G:F (- 1.99%) for nursery pigs, and decreased (P &amp;lt; 0.01) the MD of ADG (-1.68%) and G:F (-1.06%) for growing-finishing pigs. Feeding high oil (≥ 10% ether extract) cDDGS-based diets to pigs resulted in a 2.96% reduction in ADFI while feeding reduced-oil (&amp;lt; 10% ether extract) cDDGS-based diets reduced G:F by 1.56% compared with pigs fed CSB diets. Supplementation of exogenous enzymes improved (P &amp;lt; 0.05) the MD of ADG and G:F by 1.94% and 2.65%, respectively in CSB diets and by 2.67% and 1.87%, respectively, in cDDGS diets. Proteases, enzyme cocktails, or xylanases improved (P &amp;lt; 0.05) ADG by 7.29%, 2.64% and 2.48% in pigs fed CSB-based diet, respectively. In conclusion, cDDGS-based diets slightly reduces growth performance of nursery and growing-finishing pigs, but supplementation of xylanase or enzyme cocktail improves G:F of pigs fed cDDGS-based diets

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PSVI-5 Effects of Feeding Corn Distillers Dried Grains with Solubles (cDDGS) Diets with and Without Supplemental Enzymes on Growth Performance of Pigs: A Meta-analysis