Open AccessDual-Mode Gradient HPLC and TLC Densitometry Methods for the Simultaneous Determination of Paracetamol and Methionine in the Presence of Paracetamol Impurities
Author(s) -
Hany Ibrahim,
Abdallah M. Hamdy,
Hanan A. Merey,
Ahmed S. Saad
Publication year - 2021
Publication title -
journal of aoac international
Language(s) - English
Resource type - Journals
eISSN - 1944-7922
pISSN - 1060-3271
DOI - 10.1093/jaoacint/qsab021
Subject(s) - chromatography , chemistry , high performance liquid chromatography , densitometry , methanol , excipient , pharmaceutical formulation , organic chemistry , physics , quantum mechanics
Paracetamol (PC) is one of the most widely used analgesic and antipyretic drugs and has recently been integrated into the supportive therapy of COVID-19. Pharmaceuticals containing methionine (MT) with PC may contribute to avoid hepatotoxicity and eventual PC overdose-dependent death.