Open AccessImmunotherapy-related adverse events (irAEs): extraction from FDA drug labels and comparative analysis
Author(s) -
QuanQiu Wang,
Rong Xu
Publication year - 2018
Publication title -
jamia open
Language(s) - English
Resource type - Journals
ISSN - 2574-2531
DOI - 10.1093/jamiaopen/ooy045
Subject(s) - adverse effect , medicine , drug , food and drug administration , immunotherapy , broad spectrum , clinical research , endocrine system , immune system , oncology , cancer , pharmacology , immunology , chemistry , combinatorial chemistry , hormone
Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes in cancer patients. However, ICIs are associated with significant immune-related adverse events (irAEs) and the underlying biological mechanisms are not well-understood. To ensure safe cancer treatment, research efforts are needed to comprehensively detect and understand irAEs.