Open AccessComputational drug repositioning of atorvastatin for ulcerative colitis
Author(s) -
Lawrence Bai,
Madeleine Scott,
Ethan Steinberg,
Laurynas Kalesinskas,
Aida Habtezion,
Nigam H. Shah,
Purvesh Khatri
Publication year - 2021
Publication title -
journal of the american medical informatics association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.614
H-Index - 150
eISSN - 1527-974X
pISSN - 1067-5027
DOI - 10.1093/jamia/ocab165
Subject(s) - medicine , atorvastatin , drug repositioning , cohort , ulcerative colitis , clinical trial , oncology , retrospective cohort study , drug , colectomy , disease , pharmacology
Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC would identify a robust transcriptomic signature to improve identification of FDA-approved drugs that can be repurposed to treat patients with UC.