Open AccessThe Effects of Gamma Irradiation on Chemical Biomarker Recovery from Mixed Chemical/Biological Threat Exposure Specimens
Author(s) -
Samantha L. Isenberg,
Melissa D. Carter,
Jonathan L. Moon,
Sarah Laughlin,
Marla Petway,
Mike A. Mojica,
Julia E. Rood,
Alexis K Gursky,
Cody I. Sheppard,
Dennis A. Bagarozzi,
James L. Pirkle,
Rudolph C. Johnson
Publication year - 2020
Publication title -
the journal of applied laboratory medicine
Language(s) - English
Resource type - Journals
eISSN - 2576-9456
pISSN - 2475-7241
DOI - 10.1093/jalm/jfz022
Subject(s) - irradiation , analyte , sterilization (economics) , chemistry , radiochemistry , chromatography , physics , nuclear physics , monetary economics , economics , foreign exchange market , foreign exchange
Irradiative sterilization of clinical specimens prior to chemical laboratory testing provides a way to not only sterilize pathogens and ensure laboratorian safety but also preserve sample volume and maintain compatibility with quantitative chemical diagnostic protocols. Since the compatibility of clinical biomarkers with gamma irradiation is not well characterized, a subset of diagnostic biomarkers ranging in molecular size, concentration, and clinical matrix was analyzed to determine recovery following gamma irradiation.