Manufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study | Zendy

Omar Toubat | Zendy; Anders H. Berg | Zendy; Kimia Sobhani | Zendy; Karen Mulligan | Zendy; Acacia M Hori | Zendy; Jay Bhattacharya | Zendy; Neeraj Sood | Zendy

Open Access

Manufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study

Author(s) -

Omar Toubat,

Anders H. Berg,

Kimia Sobhani,

Karen Mulligan,

Acacia M Hori,

Jay Bhattacharya,

Neeraj Sood

Publication year - 2022

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1093/jalm/jfac034

Subject(s) - medicine , receiver operating characteristic , serostatus , incidence (geometry) , cutoff , serology , cohort , covid-19 , cumulative incidence , antibody , immunology , viral load , mathematics , disease , human immunodeficiency virus (hiv) , physics , geometry , quantum mechanics , infectious disease (medical specialty)

The objective of this analysis was to compare the performance sensitivity and specificity of manufacturer-recommended signal-to-cutoff (S/Co) thresholds with modified S/Co values to estimate the prevalence of SARS-CoV-2-specific antibodies in a cohort of firefighters with a known infection history.

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