Open AccessManufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study
Author(s) -
Omar Toubat,
Anders H. Berg,
Kimia Sobhani,
Karen Mulligan,
Acacia M Hori,
Jay Bhattacharya,
Neeraj Sood
Publication year - 2022
Publication title -
the journal of applied laboratory medicine
Language(s) - English
Resource type - Journals
eISSN - 2576-9456
pISSN - 2475-7241
DOI - 10.1093/jalm/jfac034
Subject(s) - medicine , receiver operating characteristic , serostatus , incidence (geometry) , cutoff , serology , cohort , covid-19 , cumulative incidence , antibody , immunology , viral load , mathematics , disease , human immunodeficiency virus (hiv) , physics , geometry , quantum mechanics , infectious disease (medical specialty)
The objective of this analysis was to compare the performance sensitivity and specificity of manufacturer-recommended signal-to-cutoff (S/Co) thresholds with modified S/Co values to estimate the prevalence of SARS-CoV-2-specific antibodies in a cohort of firefighters with a known infection history.