Open AccessD-Dimer and Fibrin Degradation Products Impair Platelet Signaling: Plasma D-Dimer Is a Predictor and Mediator of Platelet Dysfunction During Trauma
Author(s) -
Christopher C. Verni,
Antonio Dávila,
Carrie A. Sims,
Scott L. Diamond
Publication year - 2020
Publication title -
the journal of applied laboratory medicine
Language(s) - English
Resource type - Journals
eISSN - 2576-9456
pISSN - 2475-7241
DOI - 10.1093/jalm/jfaa047
Subject(s) - platelet , gpvi , chemistry , fibrin , platelet activation , fibrinolysis , d dimer , thrombin , calcium , medicine , immunology , endocrinology
Platelet dysfunction often accompanies trauma-induced coagulopathy. Because soluble fibrin impairs platelet glycoprotein VI (GPVI) signaling and platelets of trauma patients can display impaired calcium mobilization, we explored the role of fibrinolysis on platelet dysfunction during trauma.