Open AccessClinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors
Author(s) -
Patrick Gutschow,
Huiling Han,
Gordana Olbina,
Keith Westerman,
Elizabeta Nemeth,
Tomas Ganz,
Karen A. F. Copeland,
Mark Westerman,
V. E. Ostland
Publication year - 2020
Publication title -
the journal of applied laboratory medicine
Language(s) - English
Resource type - Journals
eISSN - 2576-9456
pISSN - 2475-7241
DOI - 10.1093/jalm/jfaa038
Subject(s) - hepcidin , ferritin , immunoassay , iron deficiency , transferrin , medicine , area under the curve , endocrinology , immunology , chemistry , anemia , antibody
Serum markers currently used as indicators of iron status have clinical limitations. Hepcidin, a key regulator of iron homeostasis, is reduced in iron deficiency (ID) and increased in iron overload. We describe the first CLIA-validated immunoassay with excellent accuracy and precision to quantify human serum hepcidin. Its diagnostic utility for detecting ID in first-time blood donors was demonstrated.