Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts | Zendy

Francisca Palomares-Alonso | Zendy; Juan Carlos Piliado | Zendy; Guadalupe Palencia | Zendy; Alma OrtizPlata | Zendy; Helgi Jung–Cook | Zendy

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Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts

Author(s) -

Francisca Palomares-Alonso,

Juan Carlos Piliado,

Guadalupe Palencia,

Alma OrtizPlata,

Helgi Jung–Cook

Publication year - 2006

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkl463

Subject(s) - albendazole , taenia crassiceps , nitazoxanide , pharmacology , neurocysticercosis , anthelmintic , praziquantel , biology , chemistry , medicine , pathology , immunology , helminths , schistosomiasis , cestoda , ecology

Neurocysticercosis is a common parasitic disease in the CNS in humans caused by the metacestode Taenia solium, with high incidence in developing countries. Albendazole is the drug of choice. However, a wide interindividual variability in the response has been reported. In order to evaluate alternative treatment options, the in vitro efficacy of nitazoxanide, its main metabolite tizoxanide as well as the tizoxanide and albendazole sulphoxide combination was tested against Taenia crassiceps cysts.

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