Open AccessPharmacokinetics of bedaquiline in cerebrospinal fluid (CSF) in patients with pulmonary tuberculosis (TB)
Author(s) -
Caryn M. Upton,
Chanel I Steele,
Gary Maartens,
Andreas H. Diacon,
Lubbe Wiesner,
Kelly E. Dooley
Publication year - 2022
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkac067
Subject(s) - bedaquiline , medicine , cerebrospinal fluid , pharmacokinetics , tuberculosis , tuberculous meningitis , lumbar puncture , pharmacology , pathology , mycobacterium tuberculosis
With current treatment options most patients with CNS TB develop severe disability or die. Drug-resistant tuberculous meningitis is nearly uniformly fatal. Novel treatment strategies are needed. Bedaquiline, a potent anti-TB drug, has been reported to be absent from CSF in a single report.