Open AccessHIV-1 drug resistance mutations among individuals with low-level viraemia while taking combination ART in Botswana
Author(s) -
Ontlametse T. Bareng,
Sikhulile Moyo,
Melissa Zahralban-Steele,
Dorcas Maruapula,
Tsotlhe R. Ditlhako,
Baitshepi Mokaleng,
Patrick Mokgethi,
Wonderful T. Choga,
Natasha O. Moraka,
Molly Pretorius-Holme,
Madisa Mine,
Elliot Raizes,
Kesaobaka Molebatsi,
Modisa S. Motswaledi,
Irene Gobe,
Terence Mohammed,
Tendani Gaolathe,
Roger Shapiro,
Mompati Mmalane,
Joseph Makhema,
Shahin Lockman,
Max Essex,
Vlad Novitsky,
Simani Gaseitsiwe
Publication year - 2022
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkac056
Subject(s) - drug resistance , human immunodeficiency virus (hiv) , medicine , virology , antiretroviral therapy , viral load , immunology , biology , genetics
To assess whether a single instance of low-level viraemia (LLV) is associated with the presence of drug resistance mutations (DRMs) and predicts subsequent virological failure (VF) in adults receiving ART in 30 communities participating in the Botswana Combination Prevention Project.