Open AccessHigh prevalence of HIV-1 transmitted drug resistance and factors associated with time to virological failure and viral suppression in Taiwan
Author(s) -
Szu-Wei Huang,
Mei-Chen Shen,
WenHung Wang,
Wei-You Li,
Jen-Hsien Wang,
Cheng-Yin Tseng,
PoYu Liu,
Lih-Shinn Wang,
Yu-Lin Lee,
Yi-Ming Arthur Chen,
Chun-Yuan Lee,
PoLiang Lu,
Sheng-Fan Wang
Publication year - 2021
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkab361
Subject(s) - viral load , medicine , hazard ratio , drug resistance , proportional hazards model , hiv drug resistance , integrase , integrase inhibitor , virology , human immunodeficiency virus (hiv) , immunology , confidence interval , antiretroviral therapy , biology , microbiology and biotechnology
Integrase strand transfer inhibitor (InSTI)-based regimens have become the major first-line treatment for HIV-1-infected patients in Taiwan. Transmitted drug resistance (TDR) and several clinical characteristics are associated with time to virological failure or viral suppression; however, these have not been investigated in Taiwan.