Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains | Zendy

Carla C. C. R. de Carvalho | Zendy; Agustina Taglialegna | Zendy; Adriana E. Rosato | Zendy

Open Access

Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains

Author(s) -

Carla C. C. R. de Carvalho,

Agustina Taglialegna,

Adriana E. Rosato

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab356

Subject(s) - daptomycin , lipopeptide , microbiology and biotechnology , antibiotics , methicillin resistant staphylococcus aureus , staphylococcus aureus , chemistry , biology , vancomycin , bacteria , genetics

The cyclic anionic lipopeptide daptomycin is used in the treatment of severe infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance, although rare, often results in treatment failure. Paradoxically, in MRSA, daptomycin resistance is usually accompanied by a concomitant decrease in β-lactam resistance in what is known as the 'see-saw effect'. This resensitization is extensively used for the treatment of MRSA infections, by combining daptomycin and a β-lactam antibiotic, such as oxacillin.

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