Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance | Zendy

Paul C. Adamson | Zendy; Eric Y. Lin | Zendy; Sung Min Ha | Zendy; Jeffrey D. Klausner | Zendy

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Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance

Author(s) -

Paul C. Adamson,

Eric Y. Lin,

Sung Min Ha,

Jeffrey D. Klausner

Publication year - 2021

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkab262

Subject(s) - neisseria gonorrhoeae , antibiotic resistance , genome , biology , genetics , database , whole genome sequencing , mutation , microbiology and biotechnology , gene , antibiotics , computer science

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health threat. Zoliflodacin is a novel antibiotic undergoing clinical trials for the treatment of gonorrhoea. While there are limited data regarding zoliflodacin resistance in N. gonorrhoeae, three amino acid mutations have been associated with increased MICs of zoliflodacin.

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