Open AccessUsing a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance
Author(s) -
Paul C Adamson,
Eric Y. Lin,
Seung Min Ha,
Jeffrey D. Klausner
Publication year - 2021
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkab262
Subject(s) - neisseria gonorrhoeae , antibiotic resistance , genome , biology , genetics , database , whole genome sequencing , mutation , microbiology and biotechnology , antibiotics , gene , computer science
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health threat. Zoliflodacin is a novel antibiotic undergoing clinical trials for the treatment of gonorrhoea. While there are limited data regarding zoliflodacin resistance in N. gonorrhoeae, three amino acid mutations have been associated with increased MICs of zoliflodacin.