Open AccessSeeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria
Author(s) -
Saber Dini,
Sophie Zaloumis,
David J. Price,
Nathalie Gobeau,
Anne Kümmel,
Mohammed Cherkaoui,
Joerg J. Moehrle,
James S. McCarthy,
Julie A. Simpson
Publication year - 2021
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkab181
Subject(s) - malaria , combination therapy , dosing , plasmodium falciparum , artemisinin , regimen , medicine , dihydroartemisinin , pharmacology , pharmacodynamics , intensive care medicine , immunology , pharmacokinetics
The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum malaria, has been declining in malaria-endemic countries due to the emergence of malaria parasites resistant to these compounds. Novel alternative therapies are needed urgently to prevent the likely surge in morbidity and mortality due to failing ACTs.