Open AccessOptimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib
Author(s) -
David A. Butler,
Amisha P Rana,
Fiorella Krapp,
SR Patel,
Yanqin Huang,
Egon A. Ozer,
Alan R. Hauser,
Zackery P. Bulman
Publication year - 2020
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkaa480
Subject(s) - amikacin , tobramycin , aminoglycoside , gentamicin , klebsiella pneumoniae , microbiology and biotechnology , pharmacodynamics , medicine , pharmacology , antibiotics , biology , pharmacokinetics , escherichia coli , biochemistry , gene
KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib, which encodes an AME that can confer resistance to some of the commercially available aminoglycosides. We sought to determine the influence of AAC(6')-Ib in KPC-Kp on the pharmacodynamic activity of aminoglycosides.