Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib | Zendy

David A. Butler | Zendy; Amisha P. Rana | Zendy; Fiorella Krapp | Zendy; Shitalben Patel | Zendy; Yanqin Huang | Zendy; Egon A. Ozer | Zendy; Alan R. Hauser | Zendy; Zackery P. Bulman | Zendy

Open Access

Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib

Author(s) -

David A. Butler,

Amisha P. Rana,

Fiorella Krapp,

Shitalben Patel,

Yanqin Huang,

Egon A. Ozer,

Alan R. Hauser,

Zackery P. Bulman

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa480

Subject(s) - amikacin , tobramycin , aminoglycoside , gentamicin , klebsiella pneumoniae , microbiology and biotechnology , pharmacodynamics , medicine , pharmacology , antibiotics , biology , pharmacokinetics , escherichia coli , biochemistry , gene

KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib, which encodes an AME that can confer resistance to some of the commercially available aminoglycosides. We sought to determine the influence of AAC(6')-Ib in KPC-Kp on the pharmacodynamic activity of aminoglycosides.

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