β-Lactam antimicrobial pharmacokinetics and target attainment in critically ill patients aged 1 day to 90 years: the ABDose study | Zendy

D Lonsdale | Zendy; Karin Kipper | Zendy; Emma H. Baker | Zendy; Charlotte Barker | Zendy; Isobel Oldfield | Zendy; Barbara J. Philips | Zendy; A. E. Johnston | Zendy; Andrew Rhodes | Zendy; Mike Sharland | Zendy; Joseph F. Standing | Zendy

Open Access

β-Lactam antimicrobial pharmacokinetics and target attainment in critically ill patients aged 1 day to 90 years: the ABDose study

Author(s) -

D Lonsdale,

Karin Kipper,

Emma H. Baker,

Charlotte Barker,

Isobel Oldfield,

Barbara J. Philips,

A. E. Johnston,

Andrew Rhodes,

Mike Sharland,

Joseph F. Standing

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa363

Subject(s) - pharmacokinetics , medicine , nonmem , pharmacodynamics , antibiotics , population , gestational age , critically ill , pharmacology , intensive care medicine , pregnancy , genetics , environmental health , microbiology and biotechnology , biology

The pharmacokinetics of β-lactam antibiotics in critical illness remain poorly characterized, particularly in neonates, children and the elderly. We undertook a pharmacokinetic study of commonly used β-lactam antibiotics in critically ill patients of all ages. The aims were to produce a whole-life β-lactam pharmacokinetic model and describe the extent to which standard doses achieve pharmacokinetic/pharmacodynamic targets associated with clinical cure.

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