Achievement of clinical isavuconazole blood concentrations in transplant recipients with isavuconazonium sulphate capsules administered via enteral feeding tube | Zendy

Erin K McCreary | Zendy; M. Hong Nguyen | Zendy; Matthew R Davis | Zendy; Jared Borlagdan | Zendy; Ryan K. Shields | Zendy; Anthony D. Anderson | Zendy; Ryan Rivosecchi | Zendy; Rachel V Marini | Zendy; Lauren M. Sacha | Zendy; Fernanda P. Silveira | Zendy; David R. Andes | Zendy; Alexander J. Lepak | Zendy

Open Access

Achievement of clinical isavuconazole blood concentrations in transplant recipients with isavuconazonium sulphate capsules administered via enteral feeding tube

Author(s) -

Erin K McCreary,

M. Hong Nguyen,

Matthew R Davis,

Jared Borlagdan,

Ryan K. Shields,

Anthony D. Anderson,

Ryan Rivosecchi,

Rachel V Marini,

Lauren M. Sacha,

Fernanda P. Silveira,

David R. Andes,

Alexander J. Lepak

Publication year - 2020

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkaa274

Subject(s) - pharmacokinetics , medicine , enteral administration , capsule , therapeutic drug monitoring , feeding tube , absorption (acoustics) , parenteral nutrition , gastroenterology , surgery , biology , botany , physics , acoustics

Isavuconazole is a triazole antifungal available in IV and capsule formulation. Prescribing information states that capsules should not be chewed, crushed, dissolved or opened because the drug was not studied in this manner. However, considering the pharmacokinetics of the capsules, we theorized opening and sprinkling the contents into an enteral feeding tube (EFT) would result in adequate absorption and systemic concentrations of isavuconazole.

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