Open AccessAchievement of clinical isavuconazole blood concentrations in transplant recipients with isavuconazonium sulphate capsules administered via enteral feeding tube
Author(s) -
Erin K McCreary,
M. Hong Nguyen,
Matthew Davis,
Jared Borlagdan,
Ryan K. Shields,
Anthony D. Anderson,
Ryan Rivosecchi,
Rachel V Marini,
Lauren M. Sacha,
Fernanda P. Silveira,
David R. Andes,
Alexander J. Lepak
Publication year - 2020
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkaa274
Subject(s) - pharmacokinetics , medicine , enteral administration , therapeutic drug monitoring , absorption (acoustics) , capsule , adverse effect , feeding tube , gastroenterology , pharmacology , parenteral nutrition , surgery , biology , physics , botany , acoustics
Isavuconazole is a triazole antifungal available in IV and capsule formulation. Prescribing information states that capsules should not be chewed, crushed, dissolved or opened because the drug was not studied in this manner. However, considering the pharmacokinetics of the capsules, we theorized opening and sprinkling the contents into an enteral feeding tube (EFT) would result in adequate absorption and systemic concentrations of isavuconazole.