Open AccessRNA markers for ultra-rapid molecular antimicrobial susceptibility testing in fluoroquinolone-treated Klebsiella pneumoniae
Author(s) -
Xi Yang,
Marjan M. Hashemi,
Nadya Andini,
Michelle M. Li,
Shuzhen Kuang,
Karen C. Carroll,
Tza Huei Wang,
Samuel Yang
Publication year - 2020
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkaa078
Subject(s) - klebsiella pneumoniae , biology , rna , ciprofloxacin , pathogen , antibiotics , microbiology and biotechnology , gene , antimicrobial , computational biology , genetics , escherichia coli
Traditional antimicrobial susceptibility testing (AST) is growth dependent and time-consuming. With rising rates of drug-resistant infections, a novel diagnostic method is critically needed that can rapidly reveal a pathogen's antimicrobial susceptibility to guide appropriate treatment. Recently, RNA sequencing has been identified as a powerful diagnostic tool to explore transcriptional gene expression and improve AST.