Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis | Zendy

Philippe Cottagnoud | Zendy; Fernando Acosta | Zendy; M. Cottagnoud | Zendy; Martin G. Täuber | Zendy

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Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis

Author(s) -

Philippe Cottagnoud,

Fernando Acosta,

M. Cottagnoud,

Martin G. Täuber

Publication year - 2002

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/49.2.327

Subject(s) - cefepime , ceftriaxone , penicillin , microbiology and biotechnology , meningitis , streptococcus pneumoniae , cephalosporin , quinolone , medicine , antibiotics , vancomycin , antibacterial agent , biology , bacteria , antibiotic resistance , surgery , imipenem , staphylococcus aureus , genetics

In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Delta log(10) cfu/mL x h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 +/- 0.14 Delta log(10) cfu/mL x h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.

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