Open AccessNeural guidance factors as hubs of immunometabolic cross-talk
Author(s) -
Yoshimitsu Nakanishi,
Sujin Kang,
Atsushi Kumanogoh
Publication year - 2021
Publication title -
international immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.86
H-Index - 134
eISSN - 1460-2377
pISSN - 0953-8178
DOI - 10.1093/intimm/dxab035
Subject(s) - semaphorin , axon guidance , neuroscience , regulator , pi3k/akt/mtor pathway , biology , neural development , immune system , signal transduction , microbiology and biotechnology , axon , receptor , immunology , genetics , gene
Semaphorins were originally identified as axon-guidance molecules essential for neural development. In addition to their functions in the neural system, members of the semaphorin family have critical functions in many pathophysiological processes, including immune responses, bone homeostasis, cancer and metabolic disorders. In particular, several lines of evidence indicate that mammalian/mechanistic target of rapamycin (mTOR), a central regulator of cell metabolism, regulates the functions of semaphorins in various types of cells, revealing a novel link between semaphorins and cell metabolism. In this review, we discuss recent advances in the immunometabolic functions of semaphorins, with a particular focus on mTOR signaling.