Open AccessCorrelates of Nonrandom Patterns of Serotype Switching in Pneumococcus
Author(s) -
Saurabh Joshi,
Mohammad A. Al-Mamun,
Daniel M Weinberger
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz687
Subject(s) - serotype , biology , genetic diversity , bacterial capsule , streptococcus pneumoniae , lineage (genetic) , genetics , microbiology and biotechnology , genetic variation , virology , bacteria , gene , virulence , medicine , population , environmental health
Pneumococcus is a diverse pathogen, with >90 serotypes, each of which has a distinct polysaccharide capsule. Pneumococci can switch capsules, evading vaccine pressure. Certain serotype pairs are more likely to occur on the same genetic background as a results of serotype switching, but the drivers of these patterns are not well understood.