Open AccessA Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection
Author(s) -
Raymond M. Johnson,
Norma Olivares-Strank,
Gang Peng
Publication year - 2020
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz685
Subject(s) - biology , immunology , cd8 , cytotoxic t cell , mhc class ii , t cell , mhc class i , major histocompatibility complex , clone (java method) , adoptive cell transfer , chlamydia trachomatis , antigen , virology , immune system , genetics , dna , in vitro
The T-cell response to chlamydia genital tract infections in humans and mice is unusual because the majority of antigen-specific CD8 T cells are not class I restricted (referred to here as "unrestricted" or "atypical"). We previously reported that a subset of unrestricted murine chlamydia-specific CD8 T cells had a cytokine polarization pattern that included interferon (IFN)-γ and interleukin (IL)-13.