A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection | Zendy

Raymond M. Johnson | Zendy; Norma Olivares-Strank | Zendy; Gang Peng | Zendy

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A Class II-Restricted CD8γ13 T-Cell Clone Protects During Chlamydia muridarum Genital Tract Infection

Author(s) -

Raymond M. Johnson,

Norma Olivares-Strank,

Gang Peng

Publication year - 2019

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiz685

Subject(s) - biology , immunology , cd8 , cytotoxic t cell , mhc class ii , mhc class i , t cell , major histocompatibility complex , adoptive cell transfer , clone (java method) , chlamydia trachomatis , antigen , virology , immune system , genetics , dna , in vitro

The T-cell response to chlamydia genital tract infections in humans and mice is unusual because the majority of antigen-specific CD8 T cells are not class I restricted (referred to here as "unrestricted" or "atypical"). We previously reported that a subset of unrestricted murine chlamydia-specific CD8 T cells had a cytokine polarization pattern that included interferon (IFN)-γ and interleukin (IL)-13.

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