Open AccessCryptosporidium parvum Elongation Factor 1α Participates in the Formation of Base Structure at the Infection Site During Invasion
Author(s) -
Xue Yu,
Fengguang Guo,
Rola Barhoumi Mouneimne,
Guangxi Zhu
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz684
Subject(s) - cryptosporidium parvum , biology , parasite hosting , cytoplasm , intracellular parasite , vacuole , microbiology and biotechnology , cryptosporidium , intracellular , phalloidin , elongation factor , cell , virology , cytoskeleton , rna , ribosome , biochemistry , gene , world wide web , computer science , feces
Cryptosporidium is a genus of apicomplexan parasites, the causative agents of cryptosporidiosis in humans and/or animals. Although most apicomplexans parasitize within the host cell cytosols, Cryptosporidium resides on top of host cells, but it is embraced by a double-layer parasitophorous vacuole membrane derived from host cell. There is an electron-dense band to separate the parasite from host cell cytoplasm, making it as an intracellular but extracytoplasmic parasite. However, little is known on the molecular machinery at the host cell-parasite interface.