Open AccessTherapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice
Author(s) -
Jiani Wang,
Christina Ortiz,
Lindsey Fontenot,
Riya Mukhopadhyay,
Ying Xie,
Xinhua Chen,
Hanping Feng,
Charalabos Pothoulakis,
Hon Wai Koon
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz640
Subject(s) - clostridium difficile toxin a , neutralizing antibody , clostridium difficile toxin b , microbiology and biotechnology , chemokine , biology , cxcl1 , clostridium difficile , cytokine , proinflammatory cytokine , toxin , antibody , colitis , immunology , inflammation , antibiotics
Clostridium difficile infection (CDI) causes diarrhea and colitis. We aimed to find a common pathogenic pathway in CDI among humans and mice by comparing toxin-mediated effects in human and mouse colonic tissues.