Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice | Zendy

Jiani Wang | Zendy; Christina Ortiz | Zendy; Lindsey Fontenot | Zendy; Riya Mukhopadhyay | Zendy; Ying Xie | Zendy; Xinhua Chen | Zendy; Hanping Feng | Zendy; Charalabos Pothoulakis | Zendy; Hon Wai Koon | Zendy

Open Access

Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice

Author(s) -

Jiani Wang,

Christina Ortiz,

Lindsey Fontenot,

Riya Mukhopadhyay,

Ying Xie,

Xinhua Chen,

Hanping Feng,

Charalabos Pothoulakis,

Hon Wai Koon

Publication year - 2019

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiz640

Subject(s) - clostridium difficile toxin a , clostridium difficile toxin b , neutralizing antibody , microbiology and biotechnology , chemokine , clostridium difficile , cxcl1 , biology , toxin , cytokine , antibody , colitis , proinflammatory cytokine , immunology , inflammation , antibiotics

Clostridium difficile infection (CDI) causes diarrhea and colitis. We aimed to find a common pathogenic pathway in CDI among humans and mice by comparing toxin-mediated effects in human and mouse colonic tissues.

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