Open AccessZika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques
Author(s) -
Jessica El Halabi,
Brett W. Jagger,
Vanessa Salazar,
Emma S. Winkler,
James P. White,
Peter A. Humphrey,
Alec J. Hirsch,
Daniel N. Streblow,
Michael S. Diamond,
Kelle H. Moley
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz533
Subject(s) - prostatitis , zika virus , prostate , sexual transmission , virus , epididymis , immunology , infertility , male infertility , medicine , biology , virology , sperm , pregnancy , andrology , microbicide , cancer , human immunodeficiency virus (hiv) , genetics
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been correlated to lower sperm counts in ZIKV-infected humans. The prostate plays a vital role in the male reproductive tract, with acute and chronic prostatitis linked to male infertility.