Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development | Zendy

Karuna P. Karunakaran | Zendy; Hong Yu | Zendy; Xiaozhou Jiang | Zendy; Queenie W. T. Chan | Zendy; Leonard J. Foster | Zendy; Raymond M. Johnson | Zendy; Robert C. Brunham | Zendy

Open Access

Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development

Author(s) -

Karuna P. Karunakaran,

Hong Yu,

Xiaozhou Jiang,

Queenie W. T. Chan,

Leonard J. Foster,

Raymond M. Johnson,

Robert C. Brunham

Publication year - 2019

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiz522

Subject(s) - chlamydia trachomatis , biology , epitope , chlamydia , major histocompatibility complex , mhc class i , mhc class ii , antigen , immune system , t cell , immunology , effector , virology

Chlamydia trachomatis and Chlamydia muridarum are intracellular bacterial pathogens of mucosal epithelial cells. CD4 T cells and major histocompatibility complex (MHC) class II molecules are essential for protective immunity against them. Antigens presented by dendritic cells (DCs) expand naive pathogen-specific T cells (inductive phase), whereas antigens presented by epithelial cells identify infected epithelial cells as targets during the effector phase. We previously showed that DCs infected by C trachomatis or C muridarum present epitopes from a limited spectrum of chlamydial proteins recognized by Chlamydia-specific CD4 T cells from immune mice.

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