Live-Attenuated Influenza Vaccine Induces Tonsillar Follicular T Helper Cell Responses That Correlate With Antibody Induction | Zendy

Sarah Lartey | Zendy; Fan Zhou | Zendy; Karl A. Brokstad | Zendy; Kristin G. I. Mohn | Zendy; Steffen A Slettevoll | Zendy; Rishi D. Pathirana | Zendy; Rebecca Jane Cox | Zendy

Open Access

Live-Attenuated Influenza Vaccine Induces Tonsillar Follicular T Helper Cell Responses That Correlate With Antibody Induction

Author(s) -

Sarah Lartey,

Fan Zhou,

Karl A. Brokstad,

Kristin G. I. Mohn,

Steffen A Slettevoll,

Rishi D. Pathirana,

Rebecca Jane Cox

Publication year - 2019

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiz321

Subject(s) - immunology , virology , medicine , antibody response , influenza vaccine , antibody , vaccination , follicular phase , biology

Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and are crucial for generating long-term humoral immunity. However the role of TFH cells in LAIV-induced immune responses is unknown.

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