Open AccessLive-Attenuated Influenza Vaccine Induces Tonsillar Follicular T Helper Cell Responses That Correlate With Antibody Induction
Author(s) -
Sarah Lartey,
Fan Zhou,
Karl Albert Brokstad,
Kristin G. I. Mohn,
Steffen A Slettevoll,
Rishi D. Pathirana,
Rebecca Jane Cox
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz321
Subject(s) - immunology , live attenuated influenza vaccine , hemagglutination assay , vaccination , medicine , antibody , b cell , immune system , immunity , virology , influenza vaccine , titer
Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and are crucial for generating long-term humoral immunity. However the role of TFH cells in LAIV-induced immune responses is unknown.