Open AccessVaricella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells via Interleukin 6
Author(s) -
Anna Blackmon,
Christi. Como,
Andrew N. Bubak,
Teresa Mescher,
Dallas Jones,
Maria A. Nagel
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz095
Subject(s) - perineurium , cadherin , varicella zoster virus , virus , biology , microbiology and biotechnology , antibody , cell , immunology , receptor , virology , anatomy , biochemistry , genetics , peripheral nerve
In temporal arteries (TAs) from patients with giant cell arteritis, varicella zoster virus (VZV) is seen in perineurial cells that surround adventitial nerve bundles and form the peripheral nerve-extrafascicular tissue barrier (perineurium). We hypothesized that during VZV reactivation from ganglia, virus travels transaxonally and disrupts the perineurium to infect surrounding cells.