Acquisition of Antibodies Against Endothelial Protein C Receptor–Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria | Zendy

Janavi S. Rambhatla | Zendy; Louise Turner | Zendy; Laurens Manning | Zendy; Moses Laman | Zendy; Timothy M. E. Davis | Zendy; James G. Beeson | Zendy; Ivo Müeller | Zendy; Jonathan Warrel | Zendy; Thor G. Theander | Zendy; Thomas Lavstsen | Zendy; Stephen J. Rogerson | Zendy

Open Access

Acquisition of Antibodies Against Endothelial Protein C Receptor–Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria

Author(s) -

Janavi S. Rambhatla,

Louise Turner,

Laurens Manning,

Moses Laman,

Timothy M. E. Davis,

James G. Beeson,

Ivo Müeller,

Jonathan Warrel,

Thor G. Theander,

Thomas Lavstsen,

Stephen J. Rogerson

Publication year - 2018

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiy564

Subject(s) - plasmodium falciparum , malaria , antibody , erythrocyte membrane , biology , receptor , virology , endothelial protein c receptor , plasma protein binding , membrane protein , immunology , chemistry , biochemistry , membrane , thrombin , platelet

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can be classified based on their cysteine-rich interdomain region (CIDR) domains. Antibodies to different PfEMP1 types develop gradually after repeated infections as children age, and antibodies to specific CIDR types may confer protection.

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