Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo | Zendy

Nicole A. Hoff | Zendy; Patrick Mukadi | Zendy; Reena H. Doshi | Zendy; Matthew S. Bramble | Zendy; Kai Lü | Zendy; Adva Gadoth | Zendy; Cyrus Sinai | Zendy; D’Andre Spencer | Zendy; Bradley Nicholson | Zendy; Russell A. Williams | Zendy; Matthias Mossoko | Zendy; Benoit Ilunga-Kebela | Zendy; Joseph Wasiswa | Zendy; Emile Okitolonda-Wemakoy | Zendy; Vivian H. Alfonso | Zendy; Imke Steffen | Zendy; JeanJacques MuyembéTamfum | Zendy; Graham Simmons | Zendy; Anne W. Rimoin | Zendy

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Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

Author(s) -

Nicole A. Hoff,

Patrick Mukadi,

Reena H. Doshi,

Matthew S. Bramble,

Kai Lü,

Adva Gadoth,

Cyrus Sinai,

D’Andre Spencer,

Bradley Nicholson,

Russell A. Williams,

Matthias Mossoko,

Benoit Ilunga-Kebela,

Joseph Wasiswa,

Emile Okitolonda-Wemakoy,

Vivian H. Alfonso,

Imke Steffen,

JeanJacques MuyembéTamfum,

Graham Simmons,

Anne W. Rimoin

Publication year - 2018

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiy499

Subject(s) - ebola virus , seroprevalence , outbreak , medicine , ebolavirus , virology , ebola hemorrhagic fever , serology , health care , nucleoprotein , immunology , antibody , virus , economics , economic growth

Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.

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